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Uncovering the molecular mechanisms of action of Native American folk medicines

11.11.21. In time for Native American Heritage Month, Abbott Bioelectricity Lab has a paper published today in Frontiers in Physiology reporting the molecular mechanistic rationale underlying dual use by Native Americans of specific plants as both analgesics and gastrointestinal aids. The project was a collaboration with the National Park Service and specifically the Redwood Creek Vegetation Team led by Elliot Gunnison, all of whom identified and helped collect plants from Muir Woods National Monument for this study. The Ohlone and Coast Miwok peoples in particular discovered medicinal uses for many of the plants we studied, and many other tribes independently discovered similar uses for plants of the same species or genus. Our work builds on their discoveries by identifying KCNQ potassium channels as targets for both the analgesic and the gastrointestinal effects of the plants. The work is published in full online today:


https://www.frontiersin.org/articles/10.3389/fphys.2021.777057/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE



Figure 1 from the article

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