top of page

Molecular mechanisms of cocaine addiction and its suppression by carnosic acid from rosemary

In a paper published this week in Neuron, the Beier lab at UCI in collaboration with the Abbott lab describes the circuits underlying cocaine addiction, and the discovery that KCNQ3 and KCNQ5 are downregulated in the globus pallidus following cocaine administration. Remarkably, increasing KCNQ3/5 activity with carnosic acid (based on results from our prior work), a metabolite from rosemary, prevents cocaine seeking behavior in mice and could pave the way for anti-addiction therapeutics.



Comments


bottom of page